Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels

Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels.

Glucocorticoids (GCs) can damage neurons of the hippocampus, the principal target tissue in the brain for the hormone. Hippocampal neuron loss during aging in the rat is accelerated by prolonged GC exposure and decelerated by adrenalectomy. GCs appear to damage these neurons indirectly by inducing a state of vulnerability and thus impairing their capacity to survive a variety of metabolic chall...

A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults.

Glucocorticoids appear capable of damaging or destroying hippocampal neurons. There is a progressive loss of such neurons with age, and the process can be prevented by adrenalectomy at mid-age or accelerated by prolonged exposure to high circulating titers of glucocorticoids. The present study examines possible mechanisms for this steroid action. Rats were either adrenalectomized, intact, or tr...

Impact of thiamine supplementation in the reversal of ethanol induced toxicity in rats.

One of the molecular mechanisms of alcohol induced toxicities is mediated by oxidative stress. Hence our studies were focused on the effect of thiamine (antioxidant) in the reversal of alcohol induced toxicity and comparison of the reversal with abstinence. Administration of ethanol at a dose of 4 g/kg body wt/day for 90 days to Sprague Dawley rats manifested chronic alcohol induced toxicity ev...

[On the toxicity of various missle fuels].

Lactate Fuels the Neonatal Brain

brain tissue. (2) Metabolic recovery pathways are fundamentally altered when lactate or hydroxybutyrate replaces glucose as the primary oxidative substrate. The implications of this study reach beyond enhancing our understanding of how the neonatal brain functions. While the observations that lactate can serve as a substrate for the neonatal brain confirms existing knowledge, the facts that it ...